22. ICOSIM Weekly

1. The call for VitD? Cure or fake?
2. 113 RANTES citations!
3. Don’t miss the date: Blood Day Frankfurt 15.Sept 2023

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Dear friends of ICOSIM and jawbone osteoimmunology,

After the summer break with fresh forces: New and interesting in jawbone osteoimmunology!!

 

1. The call for VitD? Cure or fake?

 

Who doesn’t know it: The loud call for VitD? Under the title “Cancer Mortality” is a press release from the German Cancer Research Center (DKFZ). (Editor: Marc Fröhling) to read that according to the current study situation, vitamin D intake is associated with a reduced cancer mortality.

Are we all taking VitD now and fighting cancer!? Upon closer inspection, the DKFZ researchers found significantly lower serum levels of the pro-inflammatory tumor necrosis factor alpha (TNF alpha) and interleukin 6 and CRP in study participants under VitD substitution. Problem for us ICOSM members:

Exactly TNF alpha, IL-6 and CRP play no role according to our research in the osteoimmunology of the jawbone: All three are extremely under-expressed and therefore not a necessary target for VitD substitution as our research with IMD-Berlin shows:

On the contrary, it turns out: Since an initial activation of TNF alpha, IL-6 is essential for wound healing of an FDOK, the anti-inflammatory VitD further suppresses the osteoimmunological activation of osteoneogenesis of an FDOK.

Quintessence:

The importance of VitD remains of course. But a blanket high-dose therapy regimen for bone healing in the jaw in FDOK and implantation should be approached with due caution.

P.S. See also our publication : (Read here)

Lechner J, Aschoff J, Rudi T. The vitamin D receptor and the etiology of RANTES/CCL- expressive fatty-degenerative osteolysis of the jawbone: an interface between osteoimmunology and bone metabolism. Int J Gen Med. 2018; 11:155–66. https://doi.org/10.2147/IJGM.S152873 PMID: 29731660.

2. 113 RANTES citations!

 

Does our research with IMD-Berlin on jawbone osteoimmunology find recognition in international scientific literature?

Not without pride I note: Our publications on RANTES/CCL5 and FDOK have been cited 113 times so far (of course without self-citations).

 

Download the overview

3. Save the Date: International Blood Concentrate Day Frankfurt 15.Sept 2023

 

Topic Lechner Lecture: “Bone Ultrasound Detection of Difficult to Diagnose Bone Affections after Extraction and/or Implantation”. 

 

Download Lecture Data

 

Topic Lechner Workshop: “Between Osseointegration and Osteoimmunology– Practice of Ultrasound Sonography for Immunological Sustainability of Titanium and Ceramic Implants”

 

Download Workshop Data

 

Remain until the next ICOSIM Weekly with collegial greetings in preparation for the event in Bad Kissingen at IGAF and Blood Day with Prof. Ghanaati in Frankfurt
Your Hans Lechner

 

Your
Hans Lechner

 

21. ICOSIM Weekly

1. ICOSIM: Live surgery at Jawbone Detox Days 14/15 July
2. RANTES and developmental defects of enamel in children
3. Save the date: 17th Sep. Lecture by Dr. Lechner about Immune regulation and chronic inflammation in the jaw

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Dear ICOSIM Friends and Osteoimmunology Members,

before we say goodbye for the summer break, a short note on our own behalf:
after the 100th ICOSIM Weekly from the beginning of July, we have decided to publish the Weekly fortnightly.

Always worth reading and informative for what is new in osteoimmunology of the jaw bone!!!

1. Our JAWBONE DETOX DAYS® has been very successful

on July 14th/15th, with our colleagues from the Munich Research Team-MRI Dr. Florian Notter and Dr. Fabian Schick:

With modern digital technology, two FDOK live surgeries were transmitted from our practice clinic to the pleasant (plus 37 Celsius) hotel for the participants.

The latest findings in regulative-immunological dentistry IMMUNE DENTISTRY with revolutionary new multimodal concept for therapy planning in jaw rehabilitation and implantology were presented by Hans Lechner.


Learn more about the concept to ensure individual success in diagnosis and therapy in our upcoming JAWBONE DETOX DAYS® in the ICOSIM Weekly!

The impressive lecture by Dr. Andres Fernandez from Costa Rica contributed to the international exchange of experience and lively discussion among colleagues:

2. ARTICLE: RANTES and developmental defects of enamel in children

Who does not know it? The helpless shrug of the shoulders of worried parents: Their child already has terrible enamel defects on the milk teeth!

Here is a paper with reference to enamel defects to RANTES/CCL5: Read the paper

[Costa EM, Pinho JRO, Saraiva MdCP, Ribeiro CCC, Batista RFL, Coêlho Alves CM, et al. (2023) RANTES and developmental defects of enamel in children: a Brazilian prenatal cohort (BRISA). PLoS ONE 18(7): e0284606. https://doi.org/10.1371/journal.pone.0284606].
 

Conclusion: Lower RANTES concentrations in the blood during during pregnancy may affect the process of amelogenesis, because this chemokine affects cellular depolarization, which is induced by the sustained influx of calcium (Ca++) and the release of inflammatory inflammatory cytokines that promote cell adhesion/aggregation is triggered.

P.S. One also cites at [40] our own publication: Go to publication

Lechner J, Aschoff J, Rudi T. The vitamin D receptor and the etiology of RANTES/CCL- expressive fatty-degenerative osteolysis of the jawbone: an interface between osteoimmunology and bone metabolism. Int J Gen Med. 2018; 11:155-66. https://doi.org/10.2147/IJGM.S152873 PMID: 29731660.

3. Save the date: 17.09. Lecture by Dr. Lechner


Immune regulation and chronic inflammation in the jaw

Our connection to Integrative Oral Medicine IOM creates the International Society for Autonomic Functional Diagnostics and Regulatory Medicine IGAF.

At the IGAF Symposium in Bad Kissingen, Germany, Hans Lechner will lecture on September 17, 2023: “Immune Regulation and Chronic Inflammation in the Jaw – Data and cases on system-oriented remediation practice”.

Download Flyer
Sign up here

 

Remain until the next ICOSIM Weekly with collegial greetings in the preparations for the event in Bad Kissingen at IGAF. 

 

Your
Hans Lechner

 

Local RANTES/CCL5 expression in ‘silent inflammation’ of the jawbone and system networking – is there a link between jawbone interference field and organ disease?

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The etiology of chronic immuno-inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, tumours and arteriosclerosis is not fully understood. It is generally acknowledged that several factors are interlinked in the development of these diseases, including genetic disposition and factors such as nutrition and environment. Given that holistic dentistry has always suffered a lack of explanatory models accepted by mainstream schools of thought, evidence of the overexpression of the inflammatory chemical messenger RANTES/CCL5 in the jaw is a great advance. A literature search in Google Scholar demonstrates the massive pathogenetic involvement of local RANTES/CCL5 overexpression in the jawbone in almost all chronic conditions.

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Definition of osteoblasts and adipocytes in the bone marrow

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The translation and labelling of illuminating passages from the following article outline, in my opinion, the essence of the problem of fatty-degenerative osteonecrosis in the jawbone (FDOJ): the misdirected adipogenesis in the bone marrow of the jaw as a prerequisite for overexpressed RANTES/CCL5 signalling. I would like to make this illuminating investigation available to ICOSIM members; the essential passages are marked.

Sincerely,

J. Lechner

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