Local RANTES/CCL5 expression in ‘silent inflammation’ of the jawbone and system networking – is there a link between jawbone interference field and organ disease?

The etiology of chronic immuno-inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, tumours and arteriosclerosis is not fully understood. It is generally acknowledged that several factors are interlinked in the development of these diseases, including genetic disposition and factors such as nutrition and environment. Given that holistic dentistry has always suffered a lack of explanatory models accepted by mainstream schools of thought, evidence of the overexpression of the inflammatory chemical messenger RANTES/CCL5 in the jaw is a great advance. A literature search in Google Scholar demonstrates the massive pathogenetic involvement of local RANTES/CCL5 overexpression in the jawbone in almost all chronic conditions.


Definition of osteoblasts and adipocytes in the bone marrow

The translation and labelling of illuminating passages from the following article outline, in my opinion, the essence of the problem of fatty-degenerative osteonecrosis in the jawbone (FDOJ): the misdirected adipogenesis in the bone marrow of the jaw as a prerequisite for overexpressed RANTES/CCL5 signalling. I would like to make this illuminating investigation available to ICOSIM members; the essential passages are marked.


J. Lechner