23. ICOSIM Weekly

1. Immunological sustainability of titanium implants
2. Abstract for the article
3. Don´t miss the date:
Blood Concentrate Day Frankfurt 15. Sep. 2023

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Dear friends of ICOSIM and jawbone osteoimmunology,

 

Has implantology already reached its scientific endpoint? In the daily routine of implanting is everything perfect or are we forgetting hidden stresses on the immune system?

 

1. A possible answer is given in this Weekly – By the abstract for the latest publication of our Munich Research Team MRT:

Immunological sustainability of titanium implants?
Osteoimmunology and osseointegration in dissolved titanium particles

 

Abstract: The bone-implant contact (BIC) is the essential prerequisite for successful osseointegration and implant stability. If this BIC does not occur on the entire surface of the implant, osseointegration is disturbed and local chronic inflammations in the sense of osteoimmunology can occur. These fatty-degenerative osteonecroses of the jawbone (FDOJ) endanger the immunological sustainability of the implantation; they harm the patient systemically by local RANTES/CCL5 overexpression at the implant-bone interfaces. Since no technique has yet been developed to visualize and verify whether bone or soft tissue is actually present around implants (Albrektsson 2023), these bone marrow defects at the BIC of implants have not been explored. A computerized transalveolar ultrasound system covers that diagnostic gap of standard X-ray techniques. A clinical case presentation demonstrates the immunological relevance of the problem and shows the solution using complementary dental sonography.

 

2. Curious? This is the PDF download of the original IMPLANTS article in English

Immunological sustainability of titanium implants? 
Osteoimmunology and osseointegration in dissolved titanium particles

Download Abstract

3. Save the Date: International Blood Concentrate Day Frankfurt 15. Sep. 2023

 
 

Topic of the Dr. Lechner lecture: “Bone Ultrasound Detection of Difficult to Diagnose Bone Affections after Extraction and/or Implantation”. 

 

Download Lecture Data

 

Topic of the Dr. Lechner workshop: “Between Osseointegration and Osteoimmunology – Practice of Ultrasound Sonography for Immunological Sustainability of Titanium and Ceramic Implants”

 

Download Workshop Data

 

I remain until the next ICOSIM Weekly with collegial greetings in preparation for the event in Bad Kissingen at the IGAF and the Blood Concentrate Day with Prof. Ghanaati in Frankfurt.

 

Yours,
Hans Lechner

 

22. ICOSIM Weekly

1. The call for VitD? Cure or fake?
2. 113 RANTES citations!
3. Don’t miss the date: Blood Day Frankfurt 15.Sept 2023

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Dear friends of ICOSIM and jawbone osteoimmunology,

After the summer break with fresh forces: New and interesting in jawbone osteoimmunology!!

 

1. The call for VitD? Cure or fake?

 

Who doesn’t know it: The loud call for VitD? Under the title “Cancer Mortality” is a press release from the German Cancer Research Center (DKFZ). (Editor: Marc Fröhling) to read that according to the current study situation, vitamin D intake is associated with a reduced cancer mortality.

Are we all taking VitD now and fighting cancer!? Upon closer inspection, the DKFZ researchers found significantly lower serum levels of the pro-inflammatory tumor necrosis factor alpha (TNF alpha) and interleukin 6 and CRP in study participants under VitD substitution. Problem for us ICOSM members:

Exactly TNF alpha, IL-6 and CRP play no role according to our research in the osteoimmunology of the jawbone: All three are extremely under-expressed and therefore not a necessary target for VitD substitution as our research with IMD-Berlin shows:

On the contrary, it turns out: Since an initial activation of TNF alpha, IL-6 is essential for wound healing of an FDOK, the anti-inflammatory VitD further suppresses the osteoimmunological activation of osteoneogenesis of an FDOK.

Quintessence:

The importance of VitD remains of course. But a blanket high-dose therapy regimen for bone healing in the jaw in FDOK and implantation should be approached with due caution.

P.S. See also our publication : (Read here)

Lechner J, Aschoff J, Rudi T. The vitamin D receptor and the etiology of RANTES/CCL- expressive fatty-degenerative osteolysis of the jawbone: an interface between osteoimmunology and bone metabolism. Int J Gen Med. 2018; 11:155–66. https://doi.org/10.2147/IJGM.S152873 PMID: 29731660.

2. 113 RANTES citations!

 

Does our research with IMD-Berlin on jawbone osteoimmunology find recognition in international scientific literature?

Not without pride I note: Our publications on RANTES/CCL5 and FDOK have been cited 113 times so far (of course without self-citations).

 

Download the overview

3. Save the Date: International Blood Concentrate Day Frankfurt 15.Sept 2023

 

Topic Lechner Lecture: “Bone Ultrasound Detection of Difficult to Diagnose Bone Affections after Extraction and/or Implantation”. 

 

Download Lecture Data

 

Topic Lechner Workshop: “Between Osseointegration and Osteoimmunology– Practice of Ultrasound Sonography for Immunological Sustainability of Titanium and Ceramic Implants”

 

Download Workshop Data

 

Remain until the next ICOSIM Weekly with collegial greetings in preparation for the event in Bad Kissingen at IGAF and Blood Day with Prof. Ghanaati in Frankfurt
Your Hans Lechner

 

Your
Hans Lechner

 

21. ICOSIM Weekly

1. ICOSIM: Live surgery at Jawbone Detox Days 14/15 July
2. RANTES and developmental defects of enamel in children
3. Save the date: 17th Sep. Lecture by Dr. Lechner about Immune regulation and chronic inflammation in the jaw

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Dear ICOSIM Friends and Osteoimmunology Members,

before we say goodbye for the summer break, a short note on our own behalf:
after the 100th ICOSIM Weekly from the beginning of July, we have decided to publish the Weekly fortnightly.

Always worth reading and informative for what is new in osteoimmunology of the jaw bone!!!

1. Our JAWBONE DETOX DAYS® has been very successful

on July 14th/15th, with our colleagues from the Munich Research Team-MRI Dr. Florian Notter and Dr. Fabian Schick:

With modern digital technology, two FDOK live surgeries were transmitted from our practice clinic to the pleasant (plus 37 Celsius) hotel for the participants.

The latest findings in regulative-immunological dentistry IMMUNE DENTISTRY with revolutionary new multimodal concept for therapy planning in jaw rehabilitation and implantology were presented by Hans Lechner.


Learn more about the concept to ensure individual success in diagnosis and therapy in our upcoming JAWBONE DETOX DAYS® in the ICOSIM Weekly!

The impressive lecture by Dr. Andres Fernandez from Costa Rica contributed to the international exchange of experience and lively discussion among colleagues:

2. ARTICLE: RANTES and developmental defects of enamel in children

Who does not know it? The helpless shrug of the shoulders of worried parents: Their child already has terrible enamel defects on the milk teeth!

Here is a paper with reference to enamel defects to RANTES/CCL5: Read the paper

[Costa EM, Pinho JRO, Saraiva MdCP, Ribeiro CCC, Batista RFL, Coêlho Alves CM, et al. (2023) RANTES and developmental defects of enamel in children: a Brazilian prenatal cohort (BRISA). PLoS ONE 18(7): e0284606. https://doi.org/10.1371/journal.pone.0284606].
 

Conclusion: Lower RANTES concentrations in the blood during during pregnancy may affect the process of amelogenesis, because this chemokine affects cellular depolarization, which is induced by the sustained influx of calcium (Ca++) and the release of inflammatory inflammatory cytokines that promote cell adhesion/aggregation is triggered.

P.S. One also cites at [40] our own publication: Go to publication

Lechner J, Aschoff J, Rudi T. The vitamin D receptor and the etiology of RANTES/CCL- expressive fatty-degenerative osteolysis of the jawbone: an interface between osteoimmunology and bone metabolism. Int J Gen Med. 2018; 11:155-66. https://doi.org/10.2147/IJGM.S152873 PMID: 29731660.

3. Save the date: 17.09. Lecture by Dr. Lechner


Immune regulation and chronic inflammation in the jaw

Our connection to Integrative Oral Medicine IOM creates the International Society for Autonomic Functional Diagnostics and Regulatory Medicine IGAF.

At the IGAF Symposium in Bad Kissingen, Germany, Hans Lechner will lecture on September 17, 2023: “Immune Regulation and Chronic Inflammation in the Jaw – Data and cases on system-oriented remediation practice”.

Download Flyer
Sign up here

 

Remain until the next ICOSIM Weekly with collegial greetings in the preparations for the event in Bad Kissingen at IGAF. 

 

Your
Hans Lechner

 

20. ICOSIM Weekly – New article with op-videos – Over 44 tsd. listeners QS 24 Health TV.

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Dear ICOSIM members,

ICOSIM Weekly has not fallen asleep: I am back from vacation!

  1. In this ICOSIM Weekly the overview of four NEW broadcasts on the channel QS24 of the Swiss Health TV: We have reached more than 44.000 viewers and convinced them of the novel contents of our Integrative Oral Medicine IOM.

Please take a look for yourself and learn IOM!

Chronic diseases: Cooperation between physicians and dentists
Dr. med. dent. Dr. Johann Lechner | NaturMedizin | QS24
Health Television

Broadcast date:
Sat. 09.04.2022; 09:30 p.m.

Is stress regulation present at all?
Dr. med. dent. Dr. Johann Lechner | NaturMedizin | QS24
Health Television

Broadcast date:
Sat. 04/23/2022; 9:30 p.m.

Rantes Trigger: Firing the Cytokine Storm
Dr. med. dent. Dr. Johann Lechner | NaturMedicine | QS24
Health Television

Broadcast Date:
Sat. 05/07/2022; 9:30 p.m.

Search for the cause of dermatitis
Dr. med. dent. Dr. Johann Lechner | NaturMedizin | QS24
Health Television

Broadcast date:
Sat. 05/21/2022; 09:30 p.m.

Please note: All 19 QS 24 videos by Hans Lechner can also be viewed on our practice channel! 
YouTube Channel: Hans Lechner
  1. In the professional journal “Applied Complementary Medicine AKOM 6/2022” we have published a new article: From Holistic Dentistry to Integrative Oral Medicine – Video documentation on interference field remediation in the jaw.
AKOM articel

I wish you a lot of fun watching QS24, reading the article and watching the video – I hope it is worthwhile to get further insight into the completely new discipline of a “Maxillo-mandibular Osteoimmunology”.

and remain with best ICOSIM greetings

Your Hans Lechner

19. ICOSIM Weekly – CaviTAU goes Washington DC – Ceramic Implant Congress

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Dear ICOSIM members,

due to my vacation a today delayed ICOSIM-Weekly: Our CaviTAU developer team was in Washington DC.,USA from May 19-21, 2022 and could demonstrate the leading role of CaviTAU in the use of ceramic implants in front of more than 100 participants.

Here is the title and abstract of my talk in English:

Ultrasonography versus radiography in the assessment of jawbone density in preparation for implant placement- A novel approach

A new ultrasonography device generates an ultrasound wave and passes that wave through the jawbone, called “Trans Alveolar Ultrasonography (TAU)”. Will a newly available TAU device answer the questions:

  • Is the jawbone ready for implant insertion?
  • Or is the implant connected to persisting bone marrow defects?
  • Or connected to aseptic necrotic bone and poses a risk to implant placement?

Ultrasonography device CaviTAU® is developed for the radiation-free measurement of bone density and suitable to visualize the condition of jawbone beyond radiography. TAU device CaviTAU® displays load-free jawbones for non-problematic and durable implant insertion and is available to detect radiographically undetectable “silent inflammations” around persisting “unexplainable painful” implants.

In the daily praxis and for your daily implant success measuring bone density by TAU ultrasonography before and after implantation avoids failures. TAU protects dentists and patients from the early loss of implants. Impressive clinical cases are presented by the presenter.

TAU device CaviTAU® displays a new insight into an under recognized entity of “silent inflammation” in jawbone and is a reliable guide to “jawbone detox”. For further information please visit www.cavitau.de.

Download lecture

I wish you a lot of fun reading – I hope it is worthwhile to get further insight into the completely new field of a “Maxillo-mandibular Osteoimmunology” –

and remain with best ICOSIM greetings

Yours, Hans Lechner

18. ICOSIM Weekly – Lechner lecture DEGUZ – New publication in CeramicImplants 2/2022

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Dear ICOSIM colleagues,

First reminder: sent back the vote for ICOSIM already?

  1. In this ICOSIM Weekly for all who could not be present at the DEGUZ in Frankenthal.

    Here to download my presentation:
    Insight into the jawbone: Inflammatio due to implant? Inflammatio by Endo?

Download lecture
  1. In Ceramic Implant 2/2022 again an international publication by Hans Lechner in English with the title:
    Dental Implants and Bone Marrow Defects – Evaluation of Bone Quality by Intraoral Ultrasonography
Download article

I hope you enjoy reading this article – I hope it will be worth your while to gain further insight into the completely new field of “Maxillo-mandibular Osteoimmunology” – and I leave you with my best wishes.

and remain with best ICOSIM greetings

Yours, Hans Lechner

17. ICOSIM Weekly – General meeting circulation procedures; OR videos; next FDOJ documentary; health TV QS24.

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Dear ICOSIM colleagues,

  1. General meeting by circulation! 

    You will receive mail from ICOSIM e.V. in the next days.
    Essentially, the items on the agenda are about making the association more flexible and powerful by expanding different types of memberships.
    Additionally we have the possibility to expand and finance science and education in ICOSIM.

    I ask you to return the enclosed ballot to the business address of ICOSIM e.V. by 05/20/22.

  1. I hope that our new life surgery videos have been liked and found interest in the undeniable documentation of the existence of FDOJ pathology. As a reminder download for ICOSIM members at

ALS DE:
https://www.youtube.com/watch?v=RMtMl5aGsec&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y

Burnout DE:
https://www.youtube.com/watch?v=ZFcJWsEdfN4&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y&index=5

CFS DE:
https://www.youtube.com/watch?v=nST3-_0nitc&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y&index=4

Migraine DE:
https://www.youtube.com/watch?v=mKlIyMhPAu8&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y&index=6

In addition, here is the LINK to download FDOJ documentation for tumor patients PDF; I wish you good entertainment and profound information about CaviTAU®.

Download FDOJ-Documentation in Turmor Patients
  1. The figure shows from the weekly report of the scientific database Researchgate how far our publications get international attention: in the last week of February the curve shows more than 100 links and in 1 week up to 30 readers, from “all over the world”!
Access to PubMed, with all articles and journals

Your Hans Lechner

16. ICOSIM Weekly – Lifestream video Lechner ZWP-Online CaviTAU® – Article and discussion public Resolution No. 32.

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Dear ICOSIM colleagues,

  1. I hope you have enjoyed and found interest in our new life surgery videos, in the undeniable documentation of the existence of FDOJ pathology. This ICOSIM-Weekly extends the topic “Jawbone Detox” with the link to the livestream lecture of Hans Lechner in ZWP-online titled: “Novel imaging in the jawbone with ultrasound”.
To the ZWP notification

I wish you good entertainment and profound information about CaviTAU®

  1. Of course, the discussion about Resolution No. 32 is not letting up. I quote in excerpt:
    “The treatment of so-called NICO (Neuralgia Inducing Cavitational Osteonecrosis), fatty degenerative osteolysis/osteonecrosis in the jawbone or similar diagnoses, are medically unnecessary measures, as the effectiveness has not been proven by scientific medically based study investigations. Furthermore, the alleged clinical picture of NICO is neither listed as a disease according to the ICD10 key nor in the WHO directories. Therefore, there is no medical necessity for the performance of diagnostics and treatments of this disease, such as Cavitat diagnostics….”

Obviously, the emeritus Prof. Staehle of the University of Heidelberg is behind No.32, because he had an article written:
“Neuralgia-inducing cavitational osteonecrosis – A systematic review”

Supported with tax money from the University of Heidelberg
(See Funding information: The work was supported by the Department of Conservative Dentistry and the Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg. Caroline Sekundo is funded by the Physician Scientist Program of Heidelberg University, Faculty of Medicine).

To the article

We do not leave this article unchallenged, as an expression of a scientifically appropriate discussion.

If you want to participate in the discussion, you can read the reply of Prof. May (Uni Dresden) and Lechner:

To the discussion
Download article

The reply of the esteemed colleague Dr. Müller
(allergist/immunologist):

To the discussion
Download article

I hope you enjoy reading and remain with best ICOSIM greetings

Yours, Hans Lechner

15. ICOSIM Weekly – Life videos of FDOJ operations – DEGUZ Congress – Quotes in Science – IOM column Lechner in ZWP.

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Dear ICOSIM colleagues,

  1. The Praxisklinik Ganzheitliche ZahnMedizin in Munich produces life operation videos with clinical documentation: Impressive evidence for the practice-related representation and non-refutable existence of the pathology of “Cavity-forming osteonecrosis in the jawbone – FDOJ” and its relation to
    • lack of visualization in 2D-OPG and 3D-DVT
    • local RANTES expression
    • typical histology
    • and detection by ultrasound CaviTAU:

ALS DE:
https://www.youtube.com/watch?v=RMtMl5aGsec&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y

Burnout DE:
https://www.youtube.com/watch?v=ZFcJWsEdfN4&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y&index=5

CFS DE:
https://www.youtube.com/watch?v=nST3-_0nitc&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y&index=4

Migraine and facial pain DE:
https://www.youtube.com/watch?v=mKlIyMhPAu8&list=PL9FN-GUBKSpkGDi6idVJNGvPTsLPlEx2y&index=6

  1. This ICOSIM-Weekly would like to draw your attention repeatedly to the interesting DEGUZ-Congress in Frankenthal: We all hunger for collegial contacts and friendly exchange of information after the corona lockdowns.

    On May 7 at 12:30 p.m. Hans Lechner would like to welcome you with the lecture:
    “Insight into the jawbone: Inflammatio by implant? Inflammatio by Endo?”

To the flyer with complete program and registration
  1. The fundamental orientation of our diagnostic and therapeutic osteoimmunological approaches is highly regarded in the worldwide scientific community, with 24,297 readers of the PubMed publications of our Munich research team in the last 8 weeks! (including at least two universities)
  1. The second column by Hans Lechner on “Integrative Oral Medicine IOM” appeared in ZWP-Online 4/2022; we sincerely thank Oemus-Verlag in Leipzig for this wonderful opportunity and will have the column appear in every other ZWP!
To the ZWP-Online article

I hope you enjoy reading and remain with best ICOSIM greetings

Your Hans Lechner

14. ICOSIM Weekly – Lecture Lechner International Conference on Osteoimmunology – Testimonial RANTES – Quotes in Science

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Dear ICOSIM Colleagues,

  1. This ICOSIM Weekly reports from the International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems in Crete.


The scientific committee has accepted Hans Lechner’s presentation for May 17.

Title of the lecture:

Maxillo-mandibular Osteoimmunology – Hidden Fatty Degeneration in Jawbone Marrow as Interface to Systemic Inflammation?”

The fact that 36 international speakers with a high scientific reputation are working on the topic of osteoimmunology is a great proof that we are on the right track

  • with our RANTES research and our
  • analytical insights into the jaw bone with CaviTAU®.
  • are already working on the future of “Integrative Oral Medicine”.
Go to the full program
  1. My Facebook contacts also regularly give positive feedback on my posts. Here is a nice example of a great summary:

     Gerrit Egberts posted something Lyme Nederland:

Continue to post
  1. And here is another proof of the scientific reference of our research on RANTES and ultrasound CaviTAU:
    • The 20 PubMed indexed publications of our Munich research team are now cited in 69 other scientific publications!
    • The fundamental orientation of our diagnostic and therapeutic osteoimmunological approaches is highly regarded in the worldwide scientific community!
Download the citing publications and our contributions

I hope you enjoy reading and remain with best ICOSIM greetings

Yours, Hans Lechner