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The etiology of chronic immuno-inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, tumours and arteriosclerosis is not fully understood. It is generally acknowledged that several factors are interlinked in the development of these diseases, including genetic disposition and factors such as nutrition and environment. Given that holistic dentistry has always suffered a lack of explanatory models accepted by mainstream schools of thought, evidence of the overexpression of the inflammatory chemical messenger RANTES/CCL5 in the jaw is a great advance. A literature search in Google Scholar demonstrates the massive pathogenetic involvement of local RANTES/CCL5 overexpression in the jawbone in almost all chronic conditions.
