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Research & Evidence
Science Corner
Publications, diagnostics and literature on Maxillo-mandibular Osteoimmunology — compiled for professional colleagues and for patients seeking a well-founded assessment.
Tab: Fundamentals
The starting point
Silent inflammation in the jawbone and its systemic effects
The work centres on fatty degenerative osteonecrosis of the jawbone (FDOK / “NICO”) and its association with chronic overexpression of the chemokine RANTES/CCL5.
In addition to RANTES/CCL5, the cytokines IL-1ra and MCP-1/CCL2 are routinely evaluated. Their expression pattern allows conclusions to be drawn about the immunological activity of a section of the jaw.
The ICOSIM information is based on scientifically recognised publications.
Tab: Publications
Publications
Practice-based and user studies by clinical condition
For the education and professional information of patients whose clinical condition is associated with Maxillo-mandibular Osteoimmunology, publications on the surgical remediation of fatty degenerative osteonecrosis of the jawbone (FDOK / “NICO”) with chronic overexpression of RANTES/CCL5 are compiled here.
Topic group 01
Gynaecological degenerative diseases
Publications on the association between silent inflammation in the jawbone and gynaecological degenerative conditions, including breast cancer.
Topic group 02
Facial pain and trigeminal neuralgia
Diagnostics and surgical remediation in persistent facial pain and in neuralgiform symptoms within the area supplied by the trigeminal nerve.
Topic group 03
Neurodegenerative diseases
Silent chronic inflammation in the jawbone and neurodegenerative diseases — with a focus on chronic fatigue syndrome and multiple sclerosis.
Topic group 04
Root-filled teeth and protein degradation products
Root-filled teeth, the biochemistry of potentially arising protein degradation products (“dental toxins”) and a possible link to chronic diseases.
Examples from the collection of scientific articles
| Title | Topic |
|---|---|
| Local RANTES/CCL5 expression in “silent inflammation” of the jawbone and systemic networking – is there a link between the “jaw interference field” and organ disease? | Immunology / Cytokines |
| Billing of an FDOK according to GOZ-GOÄ and ICD-10 | Law & Billing |
| Principle-oriented dentistry | Fundamentals / Professional discussion |
| Picture documentation of Chronic Osteonecrosis/Fatty Degenerative Osteonecrosis in Jawbone (COJ/FDOJ) | Case documentation |
| Osseointegration and osteoimmunology in implantology: assessment of the immune sustainability of dental implants using advanced sonographic diagnostics | Implantology |
Note: The cytokines IL-1ra, MCP-1/CCL2 and RANTES/CCL5 in particular are evaluated.
Tab: Diagnostics
Diagnostics
CaviTAU® — transalveolar ultrasound sonography
Conventional X-ray procedures show bone marrow defects in the jaw only to a limited extent. Transalveolar ultrasound sonography is radiation-free and reveals inflammatory foci in the jawbone, which are defined by the overexpression of RANTES/CCL5.
Radiation-free
Transalveolar ultrasound sonography works without ionising radiation.
TAU unit of measurement
Bone density measurement is quantified in the TAU unit of measurement and can thus be documented.
ALARA principle
First OPG, then ultrasound assessment — a CBCT only in the event of a positive ultrasound finding (ALARA principle of the German Radiation Protection Act).
Definition of foci
Inflammatory foci are defined primarily by an overexpression of the inflammatory messenger RANTES/CCL5.
Tab: Literature
Literature & book series
Volumes I to IV: Cavitational Osteolyses of the Jawbone
The four-volume series describes the clinical picture of cavitational osteolyses of the jawbone and its immunological and systemic connections — with more than 600 colour illustrations and more than 1,100 literature citations.
4
volumes in the series
600+
colour illustrations
1,100+
literature citations
“Cavitational osteonecrosis of the jaws”
Portuguese-language edition, written by Dr. Johann Lechner together with Dr. Regeane Kaniak.
Research findings and case documentation
In addition to the book series, the association provides its members with research findings, publications and case documentation.
Read more
Professional insights in the ICOSIM Weekly
The ICOSIM Weekly provides a concise summary of new publications, patient cases and legal assessments.