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NEW PUBLICATION · 4 NOVEMBER 2026
What the histology shows
This retrospective observational study examines fatty degenerative osteonecrotic changes in the jawbone, referred to as FDOJ in the article and FDOK in German. The authors reviewed 1,958 histology reports on surgically removed specimens from one Munich centre, collected between 2008 and 2020. Scar-associated nerve findings were documented in 84 reports; 31 cases were selected for more detailed description.
The reported findings include perineural fibrosis, meaning connective-tissue changes around nerves, irregular axonal sprouting and scar-neuroma-like changes. These different observations highlight peripheral nerves as a component to consider in the histological assessment of such lesions.
A research question about autonomic regulation
The paper explores whether local inflammatory signals, nerve sprouting and sympathetic activity might be connected. The proposed link involving RANTES/CCL5 and noradrenaline remains a mechanistic hypothesis. Cytokine levels and autonomic function were not measured directly in this study.
The article also describes subjective improvements in cardiovascular or autonomic symptoms after surgery. These reports were not collected using standardized measures, and there was no control group or objective cardiological follow-up. The study therefore establishes neither that FDOJ causes arrhythmias nor that surgery provides cardiovascular benefit.
For clinical practice, the publication offers a starting point for interdisciplinary discussion. Prospective studies with clearly defined outcomes are needed for a reliable clinical assessment. Unexplained arrhythmias continue to require medical and cardiological evaluation.
Lechner J, Vasconcelos e Cruz J, Seifer T, Notter F, Schick F. Peripheral Nerve Alterations in Jawbone Cavitations: Histopathological Findings from a Retrospective Observational Study. Clin Cosmet Investig Dent. 2026;18:622295.
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