{"id":3176,"date":"2021-08-26T08:32:42","date_gmt":"2021-08-26T06:32:42","guid":{"rendered":"http:\/\/icosim.de\/es\/?p=3176"},"modified":"2021-11-11T12:23:50","modified_gmt":"2021-11-11T11:23:50","slug":"28-icosim-weekly","status":"publish","type":"post","link":"https:\/\/icosim.de\/es\/28-icosim-weekly\/","title":{"rendered":"28. ICOSIM Weekly – Webinar von Innovinc"},"content":{"rendered":"\t\t
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9th<\/sup>\u00a0Edition Webinar\u00a0on\u00a0Breast Cancer by Innovinc<\/span> <\/strong><\/h2>

Dr. Lechner nimmt mit seinem Abstract \u201cJawbone Cavitation Expressed RANTES\/CCL5: Case Studies Linking Silent Inflammation in the Jawbone with Epistemology of Breast Cancer\u201d an der Webinarreihe vom 07. bis 08. Oktober via<\/strong> ZOOM Platform (London Time) von INNOVINC teil.<\/p>

Sie k\u00f6nnen sich hier f\u00fcr das Webinar anmelden: https:\/\/gicbc.org\/webinar\/registration<\/a><\/p>

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Hier finden Sie die Kurzfassung des Abstracts von Dr. Dr. Johann Lechner:<\/span><\/span><\/p>

Background<\/strong>:<\/span>\u00a0The role of signaling pathways as part of the cell-cell communication within cancer progression becomes a crucial area. Chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted), also known as the chemokine C-C motif ligand 5 (CCL5) (R\/C), is a protein on which cancer research focus due to its link with aggressive cancer development.<\/p>

Objective:<\/span>\u00a0<\/strong>Research on fatty-degenerative osteonecrosis in jawbone (FDOJ) shows striking overexpression of R\/C in these areas. Here we try to elucidate a potential link between jawbone-derived R\/C and breast cancer (BC) and compare these findings by immunohistochemical staining.<\/p>

Methods<\/strong>:<\/span> 39 FDOJ samples extracted from 39 BC patients and samples from 19 healthy control were analyzed for R\/C expression using bead-based Luminex\u00ae analysis. R\/C levels from 5 BC patients were measured\u00a0in serum\u00a0before and after FDOJ surgery. Bone density, histology, R\/C expression, and immunohistochemistry were analysed in 4 clinical case studies. The R\/C staining of two FDOJ BC patients is compared with the immunohistochemical staining of BC cell preparations.<\/p>

Results<\/strong>:<\/span> A high overexpression of R\/C was seen in all FDOJ samples. \u00a0R\/C levels in serum were statistically\u00a0downregulated after FDOJ surgery\u00a0(p=0,0241).\u00a0<\/p>

Discussion:<\/strong>\u00a0<\/span>R\/C\u00a0induced “silent inflammation” in BC are widely discussed in scientific papers along with R\/C\u00a0triggering of different signaling pathways, which might be a key point in the development of BC.\u00a0<\/p>

Conclusion<\/strong>:<\/span> Hypothesis that FDOJ may serve as a trigger of BC progression through R\/C overexpression was set by the authors, who thus\u00a0inspire clinicians to\u00a0make aware of FDOJ throughout the dental and medical community in BC cases.<\/p>

Keywords:<\/strong><\/span>\u00a0Chemokine RANTES\/CCL5; osteonecrosis of the jawbone; breast cancer; bead-based Luminex\u00ae analysis; hyperactivated signaling pathways.<\/p>

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9th\u00a0Edition Webinar\u00a0on\u00a0Breast Cancer by Innovinc Dr. Lechner nimmt mit seinem Abstract \u201cJawbone Cavitation Expressed RANTES\/CCL5: Case Studies Linking Silent Inflammation in the Jawbone with Epistemology of Breast Cancer\u201d an der Webinarreihe vom 07. bis 08. Oktober via ZOOM Platform (London Time) von INNOVINC teil. Sie k\u00f6nnen sich hier f\u00fcr das Webinar anmelden: https:\/\/gicbc.org\/webinar\/registration Hier finden […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,52],"tags":[],"class_list":["post-3176","post","type-post","status-publish","format-standard","hentry","category-allgemein","category-weekly"],"_links":{"self":[{"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/posts\/3176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/comments?post=3176"}],"version-history":[{"count":6,"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/posts\/3176\/revisions"}],"predecessor-version":[{"id":3183,"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/posts\/3176\/revisions\/3183"}],"wp:attachment":[{"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/media?parent=3176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/categories?post=3176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/icosim.de\/es\/wp-json\/wp\/v2\/tags?post=3176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}