{"id":2946,"date":"2026-09-29T01:10:46","date_gmt":"2026-09-28T23:10:46","guid":{"rendered":"https:\/\/icosim.de\/en\/science\/"},"modified":"2026-09-30T11:40:30","modified_gmt":"2026-09-30T09:40:30","slug":"science","status":"publish","type":"page","link":"https:\/\/icosim.de\/en\/science\/","title":{"rendered":"Science"},"content":{"rendered":"\n
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Home<\/a> \/<\/span> Science Corner<\/span><\/p>\n\n\n\n

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Research & Evidence<\/p>\n\n\n\n

Science Corner<\/h1>\n\n\n\n

Publications, diagnostics and literature on Maxillo-mandibular Osteoimmunology \u2014 compiled for professional colleagues and for patients seeking a well-founded assessment.<\/p>\n\n<\/div><\/div>\n\n<\/div><\/div>\n\n<\/div><\/section>\n\n\n\n

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Tab: Fundamentals<\/p>\n\n\n\n

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The starting point<\/p>\n\n\n\n

Silent inflammation in the jawbone and its systemic effects<\/h2>\n\n\n\n

The work centres on fatty degenerative osteonecrosis of the jawbone (FDOK \/ \u201cNICO\u201d) and its association with chronic overexpression of the chemokine RANTES\/CCL5.<\/p>\n\n\n\n

In addition to RANTES\/CCL5, the cytokines IL-1ra<\/strong> and MCP-1\/CCL2<\/strong> are routinely evaluated. Their expression pattern allows conclusions to be drawn about the immunological activity of a section of the jaw.<\/p>\n\n\n\n

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The ICOSIM information is based on scientifically recognised publications.<\/p>\n<\/blockquote>\n\n<\/div>\n\n\n\n

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\"Panoramic<\/figure>\n\n<\/div>\n\n<\/div>\n\n<\/div><\/section>\n\n\n\n
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Tab: Publications<\/p>\n\n\n\n

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Publications<\/p>\n\n\n\n

Practice-based and user studies by clinical condition<\/h2>\n\n\n\n

For the education and professional information of patients whose clinical condition is associated with Maxillo-mandibular Osteoimmunology, publications on the surgical remediation of fatty degenerative osteonecrosis of the jawbone (FDOK \/ \u201cNICO\u201d) with chronic overexpression of RANTES\/CCL5 are compiled here.<\/p>\n\n<\/div><\/div>\n\n\n\n

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Topic group 01<\/p>\n\n\n\n

Gynaecological degenerative diseases<\/h3>\n\n\n\n

Publications on the association between silent inflammation in the jawbone and gynaecological degenerative conditions, including breast cancer.<\/p>\n\n<\/div>\n\n\n\n

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Topic group 02<\/p>\n\n\n\n

Facial pain and trigeminal neuralgia<\/h3>\n\n\n\n

Diagnostics and surgical remediation in persistent facial pain and in neuralgiform symptoms within the area supplied by the trigeminal nerve.<\/p>\n\n<\/div>\n\n\n\n

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Topic group 03<\/p>\n\n\n\n

Neurodegenerative diseases<\/h3>\n\n\n\n

Silent chronic inflammation in the jawbone and neurodegenerative diseases \u2014 with a focus on chronic fatigue syndrome and multiple sclerosis.<\/p>\n\n<\/div>\n\n\n

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Topic group 04<\/p>\n\n\n\n

Root-filled teeth and protein degradation products<\/h3>\n\n\n\n

Root-filled teeth, the biochemistry of potentially arising protein degradation products (\u201cdental toxins\u201d) and a possible link to chronic diseases.<\/p>\n\n<\/div>\n\n<\/div>\n\n\n\n

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Go to the scientific articles<\/a><\/div>\n\n\n\n
No access yet?<\/a><\/div>\n\n<\/div>\n\n\n\n

Examples from the collection of scientific articles<\/p>\n\n\n\n

Title<\/th>Topic<\/th><\/tr><\/thead>
Local RANTES\/CCL5 expression in \u201csilent inflammation\u201d of the jawbone and systemic networking \u2013 is there a link between the \u201cjaw interference field\u201d and organ disease?<\/td>Immunology \/ Cytokines<\/td><\/tr>
Billing of an FDOK according to GOZ-GO\u00c4 and ICD-10<\/td>Law & Billing<\/td><\/tr>
Principle-oriented dentistry<\/td>Fundamentals \/ Professional discussion<\/td><\/tr>
Picture documentation of Chronic Osteonecrosis\/Fatty Degenerative Osteonecrosis in Jawbone (COJ\/FDOJ)<\/td>Case documentation<\/td><\/tr>
Osseointegration and osteoimmunology in implantology: assessment of the immune sustainability of dental implants using advanced sonographic diagnostics<\/td>Implantology<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Note:<\/strong> The cytokines IL-1ra, MCP-1\/CCL2 and RANTES\/CCL5 in particular are evaluated.<\/p>\n\n<\/div><\/div>\n\n<\/div><\/div>\n\n<\/div><\/section>\n\n\n\n

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Tab: Diagnostics<\/p>\n\n\n\n

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Diagnostics<\/p>\n\n\n\n

CaviTAU\u00ae \u2014 transalveolar ultrasound sonography<\/h2>\n\n\n\n

Conventional X-ray procedures show bone marrow defects in the jaw only to a limited extent. Transalveolar ultrasound sonography is radiation-free and reveals inflammatory foci in the jawbone, which are defined by the overexpression of RANTES\/CCL5.<\/p>\n\n\n\n

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Radiation-free<\/h4>\n\n\n\n

Transalveolar ultrasound sonography works without ionising radiation.<\/p>\n\n<\/div>\n\n\n\n

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TAU unit of measurement<\/h4>\n\n\n\n

Bone density measurement is quantified in the TAU unit of measurement and can thus be documented.<\/p>\n\n<\/div>\n\n\n\n

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ALARA principle<\/h4>\n\n\n\n

First OPG, then ultrasound assessment \u2014 a CBCT only in the event of a positive ultrasound finding (ALARA principle of the German Radiation Protection Act).<\/p>\n\n<\/div>\n\n\n\n

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Definition of foci<\/h4>\n\n\n\n

Inflammatory foci are defined primarily by an overexpression of the inflammatory messenger RANTES\/CCL5.<\/p>\n\n<\/div>\n\n<\/div>\n\n\n\n

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Visit cavitau.de<\/a><\/div>\n\n\n\n
Video on diagnostics<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n
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\"CaviTAU\u00ae<\/figure>\n\n<\/div>\n\n<\/div>\n\n<\/div><\/section>\n\n\n\n
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Tab: Literature<\/p>\n\n\n\n

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\"Book<\/figure>\n\n<\/div>\n\n\n\n
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Literature & book series<\/p>\n\n\n\n

Volumes I to IV: Cavitational Osteolyses of the Jawbone<\/h2>\n\n\n\n

The four-volume series describes the clinical picture of cavitational osteolyses of the jawbone and its immunological and systemic connections \u2014 with more than 600 colour illustrations and more than 1,100 literature citations.<\/p>\n\n\n\n

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4<\/p>\n\n\n

volumes in the series<\/p>\n<\/div>\n\n\n\n

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600+<\/p>\n\n\n

colour illustrations<\/p>\n<\/div>\n\n\n\n

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1,100+<\/p>\n\n\n

literature citations<\/p>\n<\/div>\n\n<\/div>\n\n\n\n

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Order in the shop<\/a><\/div>\n\n\n\n
Question about the book series<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n\n\n
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\u201cCavitational osteonecrosis of the jaws\u201d<\/h3>\n\n\n\n

Portuguese-language edition, written by Dr. Johann Lechner together with Dr. Regeane Kaniak.<\/p>\n\n\n\n

To the Brazil network<\/a><\/p>\n\n<\/div>\n\n\n\n

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Research findings and case documentation<\/h3>\n\n\n\n

In addition to the book series, the association provides its members with research findings, publications and case documentation.<\/p>\n\n\n\n

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To the Members’ area<\/a><\/p>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n<\/div><\/div>\n\n<\/div><\/section>\n\n\n\n

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Read more<\/p>\n\n\n\n

Professional insights in the ICOSIM Weekly<\/h2>\n\n\n\n

The ICOSIM Weekly provides a concise summary of new publications, patient cases and legal assessments.<\/p>\n\n\n\n

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To the Weekly archive<\/a><\/div>\n\n\n
Academy curriculum<\/a><\/div>\n\n<\/div>\n\n<\/div><\/div>\n\n<\/div><\/section>\n\n","protected":false},"excerpt":{"rendered":"

Home \/ Science Corner Research & Evidence Science Corner Publications, diagnostics and literature on Maxillo-mandibular Osteoimmunology \u2014 compiled for professional colleagues and for patients seeking a well-founded assessment. Tab: Fundamentals The starting point Silent inflammation in the jawbone and its systemic effects The work centres on fatty degenerative osteonecrosis of the jawbone (FDOK \/ \u201cNICO\u201d) […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2946","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/pages\/2946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/comments?post=2946"}],"version-history":[{"count":3,"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/pages\/2946\/revisions"}],"predecessor-version":[{"id":3014,"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/pages\/2946\/revisions\/3014"}],"wp:attachment":[{"href":"https:\/\/icosim.de\/en\/wp-json\/wp\/v2\/media?parent=2946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}