ICOSIM WEEKLY

2 November 2026 · Osteoimmunology & Integrative Implantology

Understanding the biology of an implant site

Dear colleagues,

An implant becomes part of living tissue. This issue looks at the biological environment around it, from bone cells and blood vessels to local immune signalling. You will also find the presentations and speakers at the ICOSIM Seminar in Munich, where these questions will be part of the discussion.

BONE BIOLOGY

Looking more closely at bone quality

The amount of available bone is an important starting point in implant planning. A biological perspective also considers the tissue itself: its cells, blood supply and the interactions between bone metabolism and the immune system.

Four connected areas provide a useful framework:

Bone cells
Osteoblasts and osteocytes are central participants in bone metabolism.

Blood supply
Microvessels and circulation form part of the local tissue environment.

Bone marrow
Blood-forming cells, fat cells and immune cells make up a complex marrow environment.

Immune regulation
Osteoimmunology explores the interactions between the immune system and bone.

For implantology, this brings the local healing environment into focus. Osteoimmunology connects the study of bone metabolism with the immune response, offering a framework for discussing how the surrounding tissue responds during integration.

RESEARCH NOTES

RANTES/CCL5 and local inflammation

RANTES, also known as CCL5, is an immune signalling molecule. Researchers studying osseointegration are investigating how signals of this kind relate to the tissue environment around implants.

In 2024, Dr. med. dent. Johann Lechner, PhD (UCN) and colleagues analysed altered jawbone marrow tissue collected after titanium-implant removal in 37 selected patients. They reported CCL5 levels above the study’s reference value. A review published in January 2026 discusses these findings within the wider molecular biology of osseointegration.

The findings raise a useful research question: what can these signals tell us about the local tissue environment? The small, selected sample does not establish a reliable diagnostic use; further clinical investigation is needed.

Read the review (2026) →

Read Dr. med. dent. Johann Lechner, PhD (UCN) et al. (2024) →

ICOSIM SEMINAR · MUNICH · 27–29 NOVEMBER 2026

Presentations and speakers

Optimizing Local Conditions for Implant Success – Evaluation of the Medullary Environment
Dr. med. dent. Johann Lechner, PhD (UCN)

Implantology is Osteoimmunology
Prof. Dr. med. Joseph Choukroun

Activating Bone Intelligence
Dr. dent. med. Tobias Steinherr, MSc

Evolution through Ceramic Thinking
Dr. med. dent. Olivier Chéron

The Immunological Fire-Wall at Ceramic Implants
Dr. med. dent. Fabian Schick

Optimizing Systemic Conditions for Implant Success – Evaluation of Immunological Regulation
Dr. med. dent. Johann Lechner, PhD (UCN)

Cranial Neural Therapy for Implantologists
Dr. med. David Vinyes

Post-Implant Immunological Rehabilitation of Impaired Medullary Metabolism – Detoxification Strategies and Infusion Therapy
Dr. med. dent. Johann Lechner, PhD (UCN)

What Is the Link Between Neural Therapy and Degenerative Osteonecrosis (FDOJ)?
Dr. med. dent. Johann Lechner, PhD (UCN)

Dental Ultrasound Imaging for the Assessment of Jawbone Density and Its Osteoimmunology
Robert Huber, MBA

Osseointegration & Osteoimmunology
Dr. dent. med. Regeane Kaniak

Practical Injection Techniques in Cranial Neural Therapy for Implantologists – Part 1
Dr. med. David Vinyes

Practical Injection Techniques in Cranial Neural Therapy for Implantologists – Part 2
Dr. med. David Vinyes

Venue: Rosenkavalierplatz 13, 81925 Munich, Germany.

We look forward to exchanging ideas with you in Munich.

The ICOSIM team

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